Polynucleotides For Face & Skin Rejuvenation

Polynucleotides (PNs) are a rising star in the field of aesthetic medicine, gaining recognition for their regenerative and rejuvenating properties. This detailed guide delves into all aspects of polynucleotides, from their composition and mechanisms of action to their applications, types, leading brands, and benefits for skin health.

What Are Polynucleotides?

Polynucleotides are naturally occurring molecules derived from DNA fragments. They consist of a chain of nucleotides the building blocks of DNA and RNA. In aesthetic medicine, polynucleotides are typically extracted from salmon DNA, which has been shown to be biocompatible and highly effective in stimulating skin repair and regeneration.

How Do Polynucleotides Work?

Polynucleotides function by promoting tissue repair and cellular regeneration. Their primary mechanisms include:
- Hydration: Polynucleotides attract and bind water molecules, enhancing skin hydration and improving texture.
- Fibroblast Stimulation: They activate fibroblasts, the cells responsible for producing collagen and elastin, leading to firmer and more youthful skin.
- Anti-inflammatory Effects: Polynucleotides help reduce inflammation, making them suitable for sensitive or compromised skin.
- Free Radical Scavenging: They neutralize free radicals, protecting the skin from oxidative stress and environmental damage.

Applications in Aesthetic Medicine

Polynucleotides are versatile and can be used in various aesthetic treatments:

1. Skin Boosters

Skin boosters containing polynucleotides are injected into the dermis to improve overall skin quality. These treatments:
- Enhance hydration and elasticity.
- Reduce the appearance of fine lines and wrinkles.
- Restore radiance and smoothness to dull, aging skin.

2. Mesotherapy

In mesotherapy, polynucleotides are delivered into the mesoderm layer of the skin using microinjections. This technique is often used to:
- Address localized skin concerns like scarring or pigmentation.
- Promote collagen synthesis for targeted rejuvenation.
- Revitalize the skin in areas such as the face, neck, hands, and decolletage.

3. Wound Healing and Scar Management

Due to their regenerative properties, polynucleotides are used to:
- Accelerate the healing of post-procedure wounds (e.g., after lasers or microneedling).
- Minimize the appearance of scars by promoting tissue remodeling.

4. Hair Restoration

Polynucleotides have shown promise in stimulating hair follicle activity and improving scalp health, making them a valuable component in hair loss treatments.

Types of Polynucleotides in Aesthetics

Polynucleotides are categorized based on their molecular weight and formulation:
- High Molecular Weight Polynucleotides: These are used for deeper skin repair and regeneration.
- Low Molecular Weight Polynucleotides: These focus on superficial hydration and texture improvement.

Some formulations combine polynucleotides with other ingredients such as hyaluronic acid, vitamins, and peptides to enhance their efficacy.

Popular Brands Offering Polynucleotide-Based Treatments

Several brands have developed innovative polynucleotide-based products. Here are some of the most notable:

Rejuran

Originating from South Korea, Rejuran (also known as PDRN therapy) is a popular polynucleotide treatment. It is often referred to as The Healers Injection due to its ability to repair damaged skin and restore a youthful glow.

Nucleofill

A leading European brand, Nucleofill offers polynucleotide-based solutions targeting hydration, anti-aging, and antioxidant protection.

Plinest

This Italian brand focuses on polynucleotide treatments for skin regeneration, particularly for sensitive areas like the under-eye region.

Riviva PN

A well-known brand offering polynucleotide-based skin boosters designed for deep hydration and tissue repair.

Curenex

Combining polynucleotides with other bioactive ingredients, Curenex delivers multi-functional skin rejuvenation.

Benefits of Polynucleotide Treatments

Polynucleotides offer a range of benefits, making them highly sought after in aesthetic medicine:

1. Improved skin elasticity and firmness.


2. Long-lasting hydration and radiance.


3. Reduction of fine lines, wrinkles, and scars.


4. Enhanced skin barrier function and resilience.


5. Minimal downtime with natural-looking results.

Who Can Benefit From Polynucleotide Treatments?

Polynucleotide-based treatments are suitable for a wide range of individuals, including:

• Those with aging, dehydrated, or dull skin.


• Individuals looking to minimize scars, stretch marks, or pigmentation.


• Patients seeking natural and non-invasive rejuvenation options.

Treatment Process and Recovery

Procedure

Polynucleotide treatments typically involve microinjections using fine needles or cannulas. Depending on the treatment area, the procedure may take 30-60 minutes.

Downtime

There is minimal downtime, with most patients experiencing mild redness or swelling that subsides within a few hours to days.

Results

Improvements can be seen within weeks, with optimal results after a series of 2-4 sessions spaced 2-4 weeks apart.

FDA Approval of Polynucleotides

Polynucleotides are widely used in aesthetic medicine globally, but their regulatory status, including FDA approval, varies by region and application. In the United States, the FDA evaluates products containing polynucleotides based on their intended use, safety, and efficacy.

Medical Device Classification

Polynucleotide-based products used in aesthetic treatments are often classified as medical devices. For example, skin boosters and injectable products may fall under Class II or III medical devices, requiring stringent testing and approval to ensure safety and effectiveness.

Drug or Biologic Status

In some cases, polynucleotides may be classified as biologics or drugs if they are intended for more therapeutic or regenerative purposes beyond cosmetics. Such classifications require extensive clinical trials and regulatory approval.

Current FDA-Approved Applications

As of now, specific polynucleotide-based products have received FDA approval for wound healing, tissue repair, and certain dermatological applications. However, their use in cosmetic skin boosters or mesotherapy may be considered off-label in the U.S., depending on the products approval status.

Global Approvals

While FDA approval is a gold standard in the U.S., many polynucleotide-based treatments are approved for aesthetic use in other regions, including Europe and Asia, under local regulatory bodies. For instance, Rejuran is widely used in South Korea and other Asian countries for skin rejuvenation.

Polynucleotides have revolutionized the field of aesthetic medicine by offering a natural, effective, and versatile solution for skin rejuvenation and repair. Whether used in skin boosters, mesotherapy, or scar management, these DNA-derived molecules provide exceptional benefits with minimal risks. As more brands and formulations emerge, polynucleotide-based treatments are poised to become a cornerstone of modern aesthetics.

FAQs

What are polynucleotides derived from?
Polynucleotides used in aesthetic medicine are typically extracted from salmon DNA due to its high biocompatibility and effectiveness in promoting skin regeneration.

Are polynucleotide treatments safe?
Yes, polynucleotide treatments are generally safe, with minimal side effects. They are biocompatible and non-immunogenic, making them suitable for most individuals.

What skin concerns can polynucleotides address?
Polynucleotides can treat various skin concerns, including fine lines, wrinkles, dehydration, dullness, scars, and stretch marks.

How long do the results last?
Results typically last 6-12 months, depending on the individual skin condition and lifestyle. Maintenance treatments can prolong the effects.

Are there any side effects?
Common side effects include mild redness, swelling, or bruising at the injection sites, which usually subside within a few days.

How many sessions are required?
A series of 2-4 sessions, spaced 2-4 weeks apart, is recommended for optimal results.

Can polynucleotides be combined with other treatments?
Yes, polynucleotides can be combined with treatments like microneedling, PRP, or laser therapies to enhance results.

Who is a good candidate for polynucleotide treatments?
Anyone with aging, dehydrated, or damaged skin can benefit from these treatments. They are also suitable for individuals looking to address scars or improve skin texture.

What is the downtime for polynucleotide treatments?
Downtime is minimal, with most patients resuming their daily activities within a day or two.

Are polynucleotide treatments painful?
The procedure involves microinjections, which may cause mild discomfort. Topical numbing cream is often applied to minimize pain.

Are polynucleotides FDA-approved?
While specific polynucleotide-based products are FDA-approved for wound healing and tissue repair, their use in aesthetic applications may vary by region.

Can polynucleotides help with hair loss?
Yes, polynucleotides have shown potential in promoting hair follicle activity and improving scalp health, making them useful in hair restoration treatments.

How do polynucleotides differ from hyaluronic acid?
While hyaluronic acid primarily focuses on hydration, polynucleotides also promote skin regeneration and collagen production.

Are polynucleotides suitable for sensitive skin?
Yes, their anti-inflammatory properties make them ideal for sensitive or compromised skin.

What is the cost of polynucleotide treatments?
The cost varies depending on the brand, treatment area, and number of sessions, typically ranging at GoldyZ, Multan from PKR. 20,000 - 60,000 per session.